Acute Leukemias

Strength in numbers

Acute myeloid leukemia (AML) is a type of blood cancer that starts in bone marrow, and affects the development of red blood cells, white blood cells, and platelets. There are many different subtypes of AML, which are categorized and treated based on genetic mutations and other features. Acute lymphoblastic leukemia (ALL) is another type of blood cancer that starts in bone marrow, primarily affecting white blood cells.1,2

In adults, AML is the most common acute leukemia worldwide3

AML accounts for about 23% of the world’s leukemia cases per year3

There are about 120,000 new cases of AML per year globally4

In children and young adults under 20 years old, AML makes up 74% of acute leukemia cases5

PATIENT AND CAREGIVER RESOURCES

During this time, arming yourself with information about your disease can be empowering. National cancer organizations and patient advocacy groups can provide a supportive community to help you get started. Their aim is to help people live longer, healthier lives by advancing research, raising awareness, and providing emotional and financial support to patients and their families.

AMERICAN CANCER SOCIETY

Get in-depth information on AML and ALL, treatment costs and insurance coverage, finding support groups, and ways to help advance cancer research.

NCCN PATIENT GUIDELINES

Consult comprehensive, up-to-date guidelines that detail the sequential management decisions and interventions that currently apply to AML and ALL.

LEUKEMIA & LYMPHOMA SOCIETY

Connect with the blood cancer community, along with other patients and caregivers through chats, support groups, and peer-to-peer programs, or speak with a specialist to get personalized disease and treatment information.

ACUTE LEUKEMIA ADVOCATES NETWORK (ALAN)

ALAN is a global network of patient alliances dedicated to fostering patient advocacy within acute leukemias.

YOUR UNIQUE ACUTE LEUKEMIA6

A number of genetic factors could be driving, or contributing to, your particular acute leukemia. Understanding which genes are involved in your cancer is important, because it can help your doctor decide on the treatment path that’s best for you.

WHAT DRIVES YOUR AML?6-8

Certain genetic alterations—including mutations and rearrangements—are known to “drive” acute leukemia, and are often used to predict outcomes and guide treatment selections. Some genetic alterations have targeted therapies indicated for patients with acute leukemia, while others are being studied in clinical trials.

A TAILORED TREATMENT PLAN9,10

According to NCCN—an alliance of cancer centers that are considered the leading authority in how cancer is managed—AML and ALL care can include any one or a combination of:

  • CHEMOTHERAPY11,12

    Chemotherapy is a drug treatment that uses chemicals to destroy fast-growing cells by disrupting the way they grow and divide.

    While this kind of treatment kills tumor cells, it can also destroy healthy cells in the process. Determining whether intensive chemotherapy or nonintensive chemotherapy is appropriate for a patient is often the first treatment decision point.

  • TARGETED THERAPY11

    Targeted therapies act on specific genetic mutations or molecules that may be helping cancer cells grow and survive.

  • BONE MARROW TRANSPLANT13

    A bone marrow transplant is a procedure that replaces damaged cells with healthy stem cells.

  • CLINICAL TRIALS13

    For people who lack effective treatment options, clinical trials give early access to investigational therapies that may benefit them.

STANDARD TREATMENT OF MANY LEUKEMIAS GENERALLY OCCURS IN PHASES14

Often the treatment of acute leukemia depends less on how far the disease has advanced than on the patient’s age and overall health.

PHASE OF THERAPY
OBJECTIVE/INTENT
TREATMENT OPTIONS

INDUCTION THERAPY1,13,15

Kill most of the leukemia cells in the blood and bone marrow and restore normal blood cell production; to go into remission

  • Chemotherapy
  • Targeted therapy

CONSOLIDATION THERAPY1,13,15

For people in remission following induction therapy to destroy any remaining leukemia in the body

  • Chemotherapy
  • Targeted therapy
  • Transplant*

MAINTENANCE THERAPY†,1,15,16

Prevent the leukemia from returning

  • Hypomethylating agents

THERAPY FOR RELAPSE2,15,17

When leukemia returns after a period of remission (relapses), the goal of treatment is to achieve remission again

  • Targeted therapy
  • Aggressive chemotherapy*
  • Hypomethylating agents

*For people who meet certain criteria depending on their overall physical health.
†Not everyone will receive maintenance therapy. It may be recommended depending on your type of disease, consolidation, and risk of relapse.

ADVOCATING FOR YOUR CARE

It’s important to advocate for your care and find the right tools and information for your unique needs. Many people feel empowered when they can play an active role in their treatment plan. To help ensure that you get care that’s suited to you, consider asking your doctor the following questions, and having someone with you to help listen and take notes:

Have I had any tests that show the genetic factors behind my cancer? If so, when and how often should testing occur?

What types of genetic tests are available for my type of cancer? Who administers these tests, and how are they performed?

Are there any targeted treatments available or in clinical trials that target these genetic factors?

Are there any clinical trials that I would be eligible for that we should consider?

View a variety of printable question guides from the Leukemia & Lymphoma Society (LLS).

These are just a few suggestions to get you started. Don’t be afraid to speak up, ask any questions you have, and discuss your care plan with your cancer care team.

REFERENCES

  • 1. National Comprehensive Cancer Network. NCCN Guidelines for Patients: Acute Myeloid Leukemia. 2020. Accessed October 19, 2021. 2. Mayo Clinic. Acute lymphocytic leukemia. Accessed June 17, 2021. https://www.mayoclinic.org/diseases-conditions/acutelymphocytic-leukemia/symptoms-causes/syc-20369077 3. Dong Y, Shi O, Zeng Q, et al. Leukemia incidence trends at the global, regional, and national level between 1990 and 2017. Exp Hematol Oncol. 2020;9:14. 4. Yi M, Li A, Zhou L, Chu Q, Song Y, Wu K. The global burden and attributable risk factor analysis of acute myeloid leukemia in 195 countries and territories from 1990 to 2017: estimates based on the global burden of disease study 2017. J Hematol Oncol. 2020;13(1):72. 5. Cancer.Net. Leukemia – acute lymphocytic – ALL: statistics. January 2021. Accessed June 17, 2021. https://www.cancer.net/cancer-types/ leukemia-acute-lymphocytic-all/statistics 6. DiNardo CD, Cortes JE. Mutations in AML: prognostic and therapeutic implications. Hematology. 2016(1):348-355. 7. Klossowski S, Miao H, Kempinska K, et al. Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia. J Clin Invest. 2020;130(2):981-997. 8. Papaemmanuil E, Gerstung M, Bullinger L, et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med. 2016;374(23):2209-2221. 9. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Acute Myeloid Leukemia V.3.2021. © National Comprehensive Cancer Network, Inc. 2021. All rights reserved. Accessed October 19, 2021. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way. 10. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Acute Lymphoblastic Leukemia V.2.2021. © National Comprehensive Cancer Network, Inc. 2021. All rights reserved. Accessed October 19, 2021. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way. 11. American Cancer Society. How chemotherapy drugs work. Revised November 22, 2019. Accessed June 17, 2021. https:// www.cancer.org/treatment/treatments-and-side-effects/treatment-types/chemotherapy/how-chemotherapy-drugs-work.html 12. Ferrara F, Barosi G, Venditti A, et al. Consensus-based definition of unfitness to intensive and nonintensive chemotherapy in acute myeloid leukemia: a project of SIE, SIES and GITMO group on a new tool for therapy decision making. Leukemia. 2013;27(5):997-999.13. Mayo Clinic. Acute myelogenous leukemia diagnosis and treatment. Accessed October 15, 2021. https://www.mayoclinic.org/diseases-conditions/acute-myelogenous-leukemia/diagnosis-treatment/drc-20369115 14. Harvard Health Publishing. Leukemia. Published December 12, 2014. Accessed June 17, 2021. https://www.health.harvard.edu/cancer/leukemia 15. National Comprehensive Cancer Network. NCCN Guidelines for Patients: Acute Lymphoblastic Leukemia. 2021. Accessed October 19, 2021. 16. Reville PK, Kadia TM. Maintenance Therapy in AML. Front Oncol. 2021;10:619085. 17. DeWolf S, Tallman MS. How I treat relapsed or refractory AML. Blood. 2020;136(9):1023-1032.