Scientist

San Diego, CA

Are you ready to join a team committed to making a meaningful impact through precision medicine? By joining Kura, you have an opportunity to be a part of something bigger, with a lasting impact that you can be proud of.

At Kura Oncology, we hold precision medicine to a high standard, applying cutting-edge science to create a more personalized approach in the treatment of cancer. We’ve changed the paradigm and improved the science of cancer treatment. We strive to cultivate a diverse and talented professional culture driven to develop therapies and solutions that are as unique as all of us.

As we continue to build a leading biotech organization with a strong culture, relentless execution, and a patient-focused mindset, Kura is planning to grow another 25% this year. To that end, we’re looking for our next innovator to join and help make our vision a reality. To take smart risks in pursuing novel areas of drug research and development and have fun along the way.

To succeed at Kura, you need to have a demonstrated reputation for putting the patient first and foremost, and a roll-up your sleeves attitude. The ideal candidate will possess a values-driven work style where integrity and grit drive all behaviors, decisions, and actions.

We’re looking for a highly-motivated, results-orientated Scientist to join the translational science department. This is a newly created position to support projected growth.

The successful candidate will have extensive hands-on experience in mammalian cell culture techniques, cell biology, and molecular biology assays. This position will be responsible for supporting efforts towards the development of combination therapies and studying its mechanism of action in various cellular models. This position will report to the Senior Scientist and will be a critical player in the group.

ESSENTIAL JOB FUNCTIONS:

  • Design, execute, and analyze/interpret experiments to advance mechanism of action studies, develop patient responder hypotheses, elucidate mechanisms of resistance and identify rational drug combinations that can be translated to the clinic.
  • Develop assays to support biomarker selection and identification strategies to be incorporated into developmental programs.
  • Utilize broad technical expertise in cell biology, tumor cell biology, immune cell biology, and in vivo animal models to design in vitro, in vivo, and ex vivo experiments to expand understanding of our therapeutics.
  • Document experimental results and present them regularly at group meetings.
  • Contribute to lab operations as required.

JOB REQUIREMENTS:

  • Ph.D. in Biology with 0-2 years of experience in the field of oncology
  • Experience in performing drug combination studies and characterizing cancer signaling pathways.
  • Experience in genetic manipulation of cells via CRISPR and viral transduction, running cellular (2D and 3D viability, apoptotic, cell cycle), molecular and biochemical (q-PCR, western blot, ELISA, Jess) assays.
  • Experience in target validation, functional and biomarker cell-based assay development.
  • Proficient in cell biology including shRNA and CRISPR technologies.
  • Experience in epigenetic profiling studies (DNA methylation, RNA-sequencing, ChIP-sequencing and ATAC-sequencing) and strong knowledge in enhancer-mediated regulation of the genome is a plus.
  • Have deep understanding of cancer signaling pathways as evidenced by peer-reviewed publications.
  • Ability to execute and troubleshoot experiments independently.
  • Able to analyze, interpret and present data effectively.
  • Able to adapt quickly to changing needs of the company and work collaboratively.
  • Deliver results under tight deadlines.
  • Highly motivated, innovative and strong team player. Excellent time management and organizational skills.

THE KURA PACKAGE

  • Career advancement/ development opportunities
  • Competitive comp package
  • Bonus
  • 401K + employer contributions
  • Generous stock options
  • ESPP Plan
  • 20 days of PTO to start
  • 14 Holidays + 3 Floater Holidays (Including Winter Break), Summer Hours
  • Generous benefits package with a variety of plans available with a substantial employer match
  • Paid Paternity/Maternity Leave
  • In-Office catered lunches
  • Home Office Setup
  • Cell Phone and Wellness Stipend
  • Commuter Stipend (Boston Office)
  • Regular employee social activities, including happy hours, monthly birthday celebrations, Kura Koffee Talks, and much more!

Kura Oncology is a clinical-stage biopharmaceutical company discovering and developing personalized therapeutics for the treatment of solid tumors and blood cancers. The company’s diverse pipeline consists of small molecules that target cancer signaling pathways where there is a strong scientific and clinical rationale to improve outcomes by identifying those patients most likely to benefit from treatment. Kura Oncology’s approach to drug development is focused on rapidly translating novel science into life-saving medicines. Our goal is to help patients with cancer lead better, longer lives. Kura Oncology was founded in 2014 and has offices in San Diego, California, and Boston, Massachusetts.

Kura’s pipeline consists of Tipifarnib and KO-539. Tipifarnib is a farnesyl transferase inhibitor currently being evaluated in patients with certain head and neck cancers that carry HRAS mutations. KO-539 is an oral investigational drug candidate we are developing for the treatment of genetically defined AML patients with high unmet needs, currently in a Phase 1/2A clinical trial. KO-539 blocks the interaction of two proteins called menin and MLL that, together, are critically important for survival, growth, and proliferation of certain kinds of leukemia cells.

Kura Oncology is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status. To apply, please submit your resume to careers@kuraoncology.com